{"id":5037,"date":"2022-12-22T08:00:00","date_gmt":"2022-12-22T08:00:00","guid":{"rendered":"https:\/\/insulapp.pl\/?p=5037"},"modified":"2022-12-12T16:13:28","modified_gmt":"2022-12-12T16:13:28","slug":"etiology","status":"publish","type":"post","link":"https:\/\/insulapp.pl\/en\/etiology\/","title":{"rendered":"Etiology"},"content":{"rendered":"\t\t
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The authors Freeman and Pennings, in their extensive study on insulin resistance, raise the aspect of etiology, i.e. the origin, the cause of this metabolic disorder. They show that IO can be divided into acquired, hereditary and mixed, but the majority of patients with acquired insulin resistance predominate. Acquired insulin resistance is caused by the following factors:<\/p>

\u2022 Excess dysfunctional adipose tissue<\/p>

\u2022Lack of physical activity<\/p>

\u2022 Nutritional imbalance<\/p>

\u2022 Medications (glucocorticoids, anti-adrenergics, protease inhibitors, atypical antipsychotics and some exogenous insulins)<\/p>

\u2022 Increased sodium content in the diet<\/p>

\u2022 Lipotoxicity due to excess circulating free fatty acids<\/p>

In addition to the hereditary components of the above etiologies of insulin resistance, there are a number of unrelated genetic syndromes associated with insulin resistance<\/p>

\u00a0<\/p>

Source: Freeman AM, Pennings N. Insulin Resistance. [Updated 2022 Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507839\/<\/a><\/p>

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