{"id":5055,"date":"2022-12-29T08:00:00","date_gmt":"2022-12-29T08:00:00","guid":{"rendered":"https:\/\/insulapp.pl\/?p=5055"},"modified":"2022-12-12T16:27:38","modified_gmt":"2022-12-12T16:27:38","slug":"mechanisms-of-insulin-resistance","status":"publish","type":"post","link":"https:\/\/insulapp.pl\/en\/mechanisms-of-insulin-resistance\/","title":{"rendered":"Mechanisms of Insulin Resistance"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5055\" class=\"elementor elementor-5055 elementor-5047\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cf86a25 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cf86a25\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b1e054f\" data-id=\"b1e054f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e4ef093 elementor-widget elementor-widget-text-editor\" data-id=\"e4ef093\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<table><tbody><tr><td width=\"397\"><p>Insulin acts on the cells of the body through specific insulin receptors. The process of insulin action begins when its molecules attach to the receptor located on the surface<\/p><p>most body cells. Depending on the given process, its effects may be visible from a few seconds to several hours after binding to the receptor.<\/p><p>\u00a0<\/p><p>In the publication &#8220;Insulin resistance in endocrinopathies&#8221;, the authors present three mechanisms of disorders that lead to the occurrence of insulin resistance.<\/p><p>\u00a0<\/p><p>1. The mechanism of pre-receptor resistance &#8211; may be caused by the incorrect structure of insulin molecules, increased degradation of insulin, the presence of antibodies in the blood that bind insulin molecules, as well as a high concentration of hormones antagonistic to insulin &#8211; i.e. cortisol, glucagon, thyroid hormones, androgen hormones or hormone growth,<\/p><p>2. The mechanism of receptor resistance &#8211; is associated with a reduced number of insulin receptors or their affinity for insulin. It has been proven that insulin produces its maximum effect in peripheral tissues after saturation of 10% of the receptors.<\/p><p>3. The mechanism of post-receptor resistance is most often associated with disturbances in the intracellular signal transmission, i.e. the signal of insulin binding to the receptor. Post-receptor resistance can also be induced by abnormalities in the structure and operation of glucose transporters into the cell, as well as in the case of strong lipolysis, when the amount of free fatty acids increases, and their excessive oxidation inhibits glycolysis.<\/p><p>\u00a0<\/p><p>Source: \u0179r\u00f3d\u0142o: Wies\u0142aw Grzesiuk, Dorota Szydlarska, Katarzyna J\u00f3\u017awik \u201eInsulin resistance in endocrinopathies\u201d. Via Medica, 2008. ISSN 1734-3321 www.endokrynologia.viamedica.pl<\/p><\/td><\/tr><\/tbody><\/table>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Insulin acts on the cells of the body through specific insulin receptors. The process of insulin action begins when its &hellip;<\/p>\n","protected":false},"author":1,"featured_media":4503,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[60],"tags":[],"class_list":["post-5055","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.9 (Yoast SEO v23.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Mechanisms of Insulin Resistance - InsulApp<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/insulapp.pl\/en\/mechanisms-of-insulin-resistance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mechanisms of Insulin Resistance\" \/>\n<meta property=\"og:description\" content=\"Insulin acts on the cells of the body through specific insulin receptors. 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