{"id":6973,"date":"2023-03-09T07:35:00","date_gmt":"2023-03-09T06:35:00","guid":{"rendered":"https:\/\/insulapp.pl\/insulin-action-sites-and-symptoms-of-insulin-resistance-part-3\/"},"modified":"2023-03-05T19:09:25","modified_gmt":"2023-03-05T18:09:25","slug":"insulin-action-sites-and-symptoms-of-insulin-resistance-part-3","status":"publish","type":"post","link":"https:\/\/insulapp.pl\/en\/insulin-action-sites-and-symptoms-of-insulin-resistance-part-3\/","title":{"rendered":"Insulin action sites and symptoms of insulin resistance &#8211; part. 3."},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"6973\" class=\"elementor elementor-6973 elementor-6959\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-295b769 e-flex e-con-boxed e-con e-parent\" data-id=\"295b769\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2ae7ebd elementor-widget elementor-widget-text-editor\" data-id=\"2ae7ebd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<table>\n<tbody>\n<tr>\n<td width=\"387\">\n<p>Liver<\/p>\n<p align=\"justify\">Although hepatic glucose uptake is not dependent on insulin, it accounts for approximately 30% of insulin-mediated glucose binding throughout the body. Insulin is essential for key metabolic processes. Intracellular signaling stimulates glycogen synthesis, while protein synthesis and lipoprotein metabolism are modulated and gluconeogenesis and ketone body production are inhibited. The mitogenic effect of insulin (and growth hormone) is mediated by the hepatic production of insulin-like growth factors.<\/p>\n<\/p>\n<p align=\"justify\">Alterations in lipoprotein metabolism are the main hepatic manifestation of insulin resistance. Increased supply of free fatty acids and reduced catabolism by adipocytes (liver cells) resistant to insulin results in increased content of triglycerides in the liver and secretion of free fatty acids. Hepatic synthesis of C-reactive protein, fibrinogen and PAI-1 is induced in response to adipocyte-derived pro-inflammatory cytokines.<\/p>\n<\/p>\n<p><em>Source: Wilcox G. Clin Biochem Rev. 2005 May;26(2):19-39. PMID: 16278749; PMCID: PMC1204764.<\/em><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Liver Although hepatic glucose uptake is not dependent on insulin, it accounts for approximately 30% of insulin-mediated glucose binding throughout &hellip;<\/p>\n","protected":false},"author":1,"featured_media":5433,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[52],"tags":[],"class_list":["post-6973","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bez-kategorii-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.9 (Yoast SEO v23.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Insulin action sites and symptoms of insulin resistance - part. 3. - InsulApp<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/insulapp.pl\/miejsca-dzialania-insuliny-i-objawy-insulinoopornosci-cz-3\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Insulin action sites and symptoms of insulin resistance - part. 3.\" \/>\n<meta property=\"og:description\" content=\"Liver Although hepatic glucose uptake is not dependent on insulin, it accounts for approximately 30% of insulin-mediated glucose binding throughout &hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/insulapp.pl\/miejsca-dzialania-insuliny-i-objawy-insulinoopornosci-cz-3\/\" \/>\n<meta property=\"og:site_name\" content=\"InsulApp\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/InsulApp\/\" \/>\n<meta property=\"article:published_time\" content=\"2023-03-09T06:35:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-05T18:09:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/insulapp.pl\/wp-content\/uploads\/2022\/10\/naukowe.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"1200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"admin9362\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin9362\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/insulapp.pl\/miejsca-dzialania-insuliny-i-objawy-insulinoopornosci-cz-3\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/insulapp.pl\/miejsca-dzialania-insuliny-i-objawy-insulinoopornosci-cz-3\/\"},\"author\":{\"name\":\"admin9362\",\"@id\":\"https:\/\/insulapp.pl\/#\/schema\/person\/3386dac8fe526b047eb1bb517038c363\"},\"headline\":\"Insulin action sites and symptoms of insulin resistance &#8211; 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